Maddalena, Parmesan's niece, is found in a confused state outside a nightclub by Luca and Valeria, who are on patrol. She is rushed to the hospital, and it turns out that she is under the effects of a powerful drug and in danger of death. The entire District mobilizes to find those responsible for the incident, investigating the nightclub and the faculty attended by Maddalena. The District is busy with a murder case, the only witness is an autistic boy. While Giovanna, Manrico and Mauro investigate, Angela tries to communicate with the boy to get some clues. Roberto and Luca, on the other hand, are busy unmasking a magician's scam. Giovanna and Manrico, after the dramas and tensions, finally manage to clear things up and find their intimacy again. Both participate in the meeting of all the colleagues to organize the search for whoever attempted to kill Scalise.